Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Hypertension in Sub-Saharan Africa: Cross-Sectional Surveys in Four Rural and Urban Communities

Identifieur interne : 003330 ( Main/Exploration ); précédent : 003329; suivant : 003331

Hypertension in Sub-Saharan Africa: Cross-Sectional Surveys in Four Rural and Urban Communities

Auteurs : Marleen E. Hendriks [Pays-Bas] ; Ferdinand W. N. M. Wit [Pays-Bas] ; Marijke T. L. Roos [Pays-Bas] ; Lizzy M. Brewster [Pays-Bas] ; Tanimola M. Akande [Nigeria] ; Ingrid H. De Beer [Namibie] ; Sayoki G. Mfinanga [Tanzanie] ; Amos M. Kahwa [Tanzanie] ; Peter Gatongi [Kenya] ; Gert Van Rooy [Namibie] ; Wendy Janssens [Pays-Bas] ; Judith Lammers [Pays-Bas] ; Berber Kramer [Pays-Bas] ; Igna Bonfrer [Pays-Bas] ; Esegiel Gaeb [Namibie] ; Jacques Van Der Gaag [Pays-Bas] ; Tobias F. Rinke De Wit [Pays-Bas] ; Joep M. A. Lange [Pays-Bas] ; Constance Schultsz [Pays-Bas]

Source :

RBID : PMC:3299675

Abstract

Background

Cardiovascular disease (CVD) is the leading cause of adult mortality in low-income countries but data on the prevalence of cardiovascular risk factors such as hypertension are scarce, especially in sub-Saharan Africa (SSA). This study aims to assess the prevalence of hypertension and determinants of blood pressure in four SSA populations in rural Nigeria and Kenya, and urban Namibia and Tanzania.

Methods and Findings

We performed four cross-sectional household surveys in Kwara State, Nigeria; Nandi district, Kenya; Dar es Salaam, Tanzania and Greater Windhoek, Namibia, between 2009–2011. Representative population-based samples were drawn in Nigeria and Namibia. The Kenya and Tanzania study populations consisted of specific target groups. Within a final sample size of 5,500 households, 9,857 non-pregnant adults were eligible for analysis on hypertension. Of those, 7,568 respondents ≥18 years were included. The primary outcome measure was the prevalence of hypertension in each of the populations under study.

The age-standardized prevalence of hypertension was 19.3% (95%CI:17.3–21.3) in rural Nigeria, 21.4% (19.8–23.0) in rural Kenya, 23.7% (21.3–26.2) in urban Tanzania, and 38.0% (35.9–40.1) in urban Namibia. In individuals with hypertension, the proportion of grade 2 (≥160/100 mmHg) or grade 3 hypertension (≥180/110 mmHg) ranged from 29.2% (Namibia) to 43.3% (Nigeria). Control of hypertension ranged from 2.6% in Kenya to 17.8% in Namibia. Obesity prevalence (BMI ≥30) ranged from 6.1% (Nigeria) to 17.4% (Tanzania) and together with age and gender, BMI independently predicted blood pressure level in all study populations. Diabetes prevalence ranged from 2.1% (Namibia) to 3.7% (Tanzania).

Conclusion

Hypertension was the most frequently observed risk factor for CVD in both urban and rural communities in SSA and will contribute to the growing burden of CVD in SSA. Low levels of control of hypertension are alarming. Strengthening of health care systems in SSA to contain the emerging epidemic of CVD is urgently needed.


Url:
DOI: 10.1371/journal.pone.0032638
PubMed: 22427857
PubMed Central: 3299675


Affiliations:


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<addr-line>Departments of Internal and Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Internal and Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author>
<name sortKey="Akande, Tanimola M" sort="Akande, Tanimola M" uniqKey="Akande T" first="Tanimola M." last="Akande">Tanimola M. Akande</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Department of Epidemiology and Community Health, University of Ilorin Teaching Hospital, Ilorin, Nigeria</addr-line>
</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Epidemiology and Community Health, University of Ilorin Teaching Hospital, Ilorin</wicri:regionArea>
<wicri:noRegion>Ilorin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Beer, Ingrid H" sort="De Beer, Ingrid H" uniqKey="De Beer I" first="Ingrid H." last="De Beer">Ingrid H. De Beer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<addr-line>Pharmaccess Foundation, Windhoek, Namibia</addr-line>
</nlm:aff>
<country xml:lang="fr">Namibie</country>
<wicri:regionArea>Pharmaccess Foundation, Windhoek</wicri:regionArea>
<wicri:noRegion>Windhoek</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mfinanga, Sayoki G" sort="Mfinanga, Sayoki G" uniqKey="Mfinanga S" first="Sayoki G." last="Mfinanga">Sayoki G. Mfinanga</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<addr-line>NIMR, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania</addr-line>
</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>NIMR, Muhimbili Medical Research Centre, Dar es Salaam</wicri:regionArea>
<wicri:noRegion>Dar es Salaam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kahwa, Amos M" sort="Kahwa, Amos M" uniqKey="Kahwa A" first="Amos M." last="Kahwa">Amos M. Kahwa</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<addr-line>NIMR, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania</addr-line>
</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>NIMR, Muhimbili Medical Research Centre, Dar es Salaam</wicri:regionArea>
<wicri:noRegion>Dar es Salaam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gatongi, Peter" sort="Gatongi, Peter" uniqKey="Gatongi P" first="Peter" last="Gatongi">Peter Gatongi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<addr-line>MOI University School of Public Health, Eldoret, Kenya</addr-line>
</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>MOI University School of Public Health, Eldoret</wicri:regionArea>
<wicri:noRegion>Eldoret</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Rooy, Gert" sort="Van Rooy, Gert" uniqKey="Van Rooy G" first="Gert" last="Van Rooy">Gert Van Rooy</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Multidisciplinary Research Centre University of Namibia, Windhoek, Namibia</addr-line>
</nlm:aff>
<country xml:lang="fr">Namibie</country>
<wicri:regionArea>Multidisciplinary Research Centre University of Namibia, Windhoek</wicri:regionArea>
<wicri:noRegion>Windhoek</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Janssens, Wendy" sort="Janssens, Wendy" uniqKey="Janssens W" first="Wendy" last="Janssens">Wendy Janssens</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff10">
<addr-line>Faculty of Economics and Business Administration, VU University Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Faculty of Economics and Business Administration, VU University Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lammers, Judith" sort="Lammers, Judith" uniqKey="Lammers J" first="Judith" last="Lammers">Judith Lammers</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="aff11">
<addr-line>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kramer, Berber" sort="Kramer, Berber" uniqKey="Kramer B" first="Berber" last="Kramer">Berber Kramer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="aff11">
<addr-line>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author>
<name sortKey="Bonfrer, Igna" sort="Bonfrer, Igna" uniqKey="Bonfrer I" first="Igna" last="Bonfrer">Igna Bonfrer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff12">
<addr-line>Institute of Health Policy and Management, Erasmus University, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Institute of Health Policy and Management, Erasmus University, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gaeb, Esegiel" sort="Gaeb, Esegiel" uniqKey="Gaeb E" first="Esegiel" last="Gaeb">Esegiel Gaeb</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<addr-line>Namibia Institute of Pathology (NIP) Ltd, Windhoek, Namibia</addr-line>
</nlm:aff>
<country xml:lang="fr">Namibie</country>
<wicri:regionArea>Namibia Institute of Pathology (NIP) Ltd, Windhoek</wicri:regionArea>
<wicri:noRegion>Windhoek</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Der Gaag, Jacques" sort="Van Der Gaag, Jacques" uniqKey="Van Der Gaag J" first="Jacques" last="Van Der Gaag">Jacques Van Der Gaag</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Amsterdam Institute for International Development, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="aff11">
<addr-line>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Faculty of Economics and Business Administration, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author>
<name sortKey="Rinke De Wit, Tobias F" sort="Rinke De Wit, Tobias F" uniqKey="Rinke De Wit T" first="Tobias F." last="Rinke De Wit">Tobias F. Rinke De Wit</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">
<addr-line>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff2">
<addr-line>Pharmaccess Foundation, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Pharmaccess Foundation, Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lange, Joep M A" sort="Lange, Joep M A" uniqKey="Lange J" first="Joep M. A." last="Lange">Joep M. A. Lange</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">
<addr-line>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author>
<name sortKey="Schultsz, Constance" sort="Schultsz, Constance" uniqKey="Schultsz C" first="Constance" last="Schultsz">Constance Schultsz</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">
<addr-line>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint>
<date when="2012">2012</date>
</imprint>
</series>
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<textClass></textClass>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>Cardiovascular disease (CVD) is the leading cause of adult mortality in low-income countries but data on the prevalence of cardiovascular risk factors such as hypertension are scarce, especially in sub-Saharan Africa (SSA). This study aims to assess the prevalence of hypertension and determinants of blood pressure in four SSA populations in rural Nigeria and Kenya, and urban Namibia and Tanzania.</p>
</sec>
<sec>
<title>Methods and Findings</title>
<p>We performed four cross-sectional household surveys in Kwara State, Nigeria; Nandi district, Kenya; Dar es Salaam, Tanzania and Greater Windhoek, Namibia, between 2009–2011. Representative population-based samples were drawn in Nigeria and Namibia. The Kenya and Tanzania study populations consisted of specific target groups. Within a final sample size of 5,500 households, 9,857 non-pregnant adults were eligible for analysis on hypertension. Of those, 7,568 respondents ≥18 years were included. The primary outcome measure was the prevalence of hypertension in each of the populations under study.</p>
<p>The age-standardized prevalence of hypertension was 19.3% (95%CI:17.3–21.3) in rural Nigeria, 21.4% (19.8–23.0) in rural Kenya, 23.7% (21.3–26.2) in urban Tanzania, and 38.0% (35.9–40.1) in urban Namibia. In individuals with hypertension, the proportion of grade 2 (≥160/100 mmHg) or grade 3 hypertension (≥180/110 mmHg) ranged from 29.2% (Namibia) to 43.3% (Nigeria). Control of hypertension ranged from 2.6% in Kenya to 17.8% in Namibia. Obesity prevalence (BMI ≥30) ranged from 6.1% (Nigeria) to 17.4% (Tanzania) and together with age and gender, BMI independently predicted blood pressure level in all study populations. Diabetes prevalence ranged from 2.1% (Namibia) to 3.7% (Tanzania).</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Hypertension was the most frequently observed risk factor for CVD in both urban and rural communities in SSA and will contribute to the growing burden of CVD in SSA. Low levels of control of hypertension are alarming. Strengthening of health care systems in SSA to contain the emerging epidemic of CVD is urgently needed.</p>
</sec>
</div>
</front>
<back>
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<name sortKey="Van Der Gaag, Jacques" sort="Van Der Gaag, Jacques" uniqKey="Van Der Gaag J" first="Jacques" last="Van Der Gaag">Jacques Van Der Gaag</name>
<name sortKey="Van Der Gaag, Jacques" sort="Van Der Gaag, Jacques" uniqKey="Van Der Gaag J" first="Jacques" last="Van Der Gaag">Jacques Van Der Gaag</name>
<name sortKey="Wit, Ferdinand W N M" sort="Wit, Ferdinand W N M" uniqKey="Wit F" first="Ferdinand W. N. M." last="Wit">Ferdinand W. N. M. Wit</name>
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<name sortKey="Akande, Tanimola M" sort="Akande, Tanimola M" uniqKey="Akande T" first="Tanimola M." last="Akande">Tanimola M. Akande</name>
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<country name="Namibie">
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<name sortKey="De Beer, Ingrid H" sort="De Beer, Ingrid H" uniqKey="De Beer I" first="Ingrid H." last="De Beer">Ingrid H. De Beer</name>
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<name sortKey="Gaeb, Esegiel" sort="Gaeb, Esegiel" uniqKey="Gaeb E" first="Esegiel" last="Gaeb">Esegiel Gaeb</name>
<name sortKey="Van Rooy, Gert" sort="Van Rooy, Gert" uniqKey="Van Rooy G" first="Gert" last="Van Rooy">Gert Van Rooy</name>
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<country name="Tanzanie">
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<name sortKey="Mfinanga, Sayoki G" sort="Mfinanga, Sayoki G" uniqKey="Mfinanga S" first="Sayoki G." last="Mfinanga">Sayoki G. Mfinanga</name>
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<name sortKey="Kahwa, Amos M" sort="Kahwa, Amos M" uniqKey="Kahwa A" first="Amos M." last="Kahwa">Amos M. Kahwa</name>
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<country name="Kenya">
<noRegion>
<name sortKey="Gatongi, Peter" sort="Gatongi, Peter" uniqKey="Gatongi P" first="Peter" last="Gatongi">Peter Gatongi</name>
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